Pioneer transcription factors Oct4 and Sox are different for normal… Pioneer

  

Pioneer transcription factors Oct4 and Sox are different for normal… Pioneer transcription factors Oct4 and Sox are different for normal transcription factors in the following ways:They reshape the epigenome by binding to, and activating the transcription of, heterochromatic regions. These transcription factors bind to nucleosome free regions to activate gene transcription.Their misexpression in cancer can cause activation of stem cell like genes changing cell fate.They reshape the epigenome by causing histone modifications after the recruitment of histone modifying enzymes. Biology Science Biochemistry BIOC 384 Share (0)